The course and outcome were described in 150 patients. Among the group of adults and elderly patients, neurologic disorders were most frequently described (16.8%) of all these disorders, migraine was the most prevalent condition (9.6%). Among youths, the most frequently described condition was encephalitis (21.7% vs 1.2% among adults and elderly patients), with the Epstein-Barr virus being the most frequently reported pathogen (68.4% of all cases of encephalitis). Table 1 presents an overview of the many disorders, intoxications, and other conditions that have been described in the context of AIWS. A total of 132 patients were ≤18 years, with a mean age of 9 years, and 34 patients were 19 years and older, with a mean age of 40 years. Age was mentioned in 166 patients mean age was 15.5 years. Patient sex was mentioned for 162 patients 55.6% of them were male. Because one patient was described twice, 9, 10 the total number of original case descriptions was 169. 8 The majority of the remaining articles consisted of individual case descriptions. A total of 170 patients were described, 20 from one case series 7 and 48 from another case series. Of these, more than 50% were published during the prior decade. Via cross-references an additional 11 articles were found, yielding a total of 70 articles. Of these, 59 articles had AIWS as their main subject. The search terms yielded 130 hits in PubMed. This article presents an overview of the literature on AIWS published over the past 60 years and summarizes its implications for clinical practice and research. 2, – 6 AIWS symptoms have both diagnostic and therapeutic consequences that differ substantially from those in schizophrenia spectrum disorders and other hallucinatory syndromes. This renewed interest is in part because of the current possibility to explore the brain's networks responsible for mediating its symptoms with the aid of functional imaging techniques. After 60 years of relative obscurity, AIWS has begun to receive scientific attention. The name refers to Lewis Carroll's well-known children's book Alice's Adventures in Wonderland, 1 in which Alice feels (among other things) her body growing both larger and smaller ( figures 1 and and2). First described in 1955, Alice in Wonderland syndrome (AIWS) is a perceptual disorder characterized by distortions of visual perception (metamorphopsias), the body schema, and the experience of time.

Alice in wonderland model the klub 17